Directory profile for Dr. M. N. V. Ravi Kumar

Pioneering research performed by the Kumar-lab has led to the development of non-competitive active targeting carrier systems and its application to human health and diseases. Kumar-lab reported a novel strategy to engineer double-headed nanosystems by the chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces, which traditionally allows coupling of only one ligand per polymer chain (Chem. Comm. 2019). Kumar-lab employed this technology in the treatment of intraocular inflammation in a canine model (Science Advances 2020). To optimize ligand-receptor stoichiometry and to enable better targeting, very recently, the Kumar-lab reported a two-step synthesis of a novel ABA triblock copolymer of lactic acid (A block) and ethylene glycol (B block) that has periodic side chains with 6-16 free carboxylic groups for ligand conjugation (J. Am. Chem. Soc. 2017). This discovery has allowed the opening of a new avenue for lupus, a disease that represents a major medical challenge (Science Advances 2020; Highlighted in Nature Reviews Rheumatology). This work on the next generation of nanosystems has advanced fundamental understanding of blood-GUT and other biological barriers and has led to the development several patents, issued, or pending. The Kumar-lab has adopted a mixed theoretical (modeling) and experimental approach to his work and has tackled difficult and crucial subjects such as identification of ligand binding site on the receptor (ACS Appl. Bio Mater. 2019), dual drug loaded particles for combinations therapies (Nanotechnology 2010).